Volume 1 Issue 1

Research Article

Cabozantinib Loaded DSPE-PEG2000 Micelles as Delivery System: Formulation, Characterization and Cytotoxicity Evaluation

Yang Q1 , Moulder RK1 , Cohen MS2 , Cai S1 , Forrest ML1*

Cabozantinib, a potent pan-tyrosine kinase inhibitor, has been reported to provide enhanced antitumor efficacy by simultaneously inhibiting both MET and VEGF pathways, which are critical to tumor angio-genesis, survival and migration. Its very poor water solubility prevents its administration by the intra-venous route, which may be important in patients unable to take the drug PDF

Research Article

A Lanthanum-Tagged Chemotherapeutic Agent HA-Pt to Track the In Vivo Distribution of Hyaluronic Acid Complexes

Ti Z1 *, Qiuhong Y1 *, Forrest WC2 , Shuang C1 , Daniel A3 and Forrest ML1

Hyaluronic acid drug conjugates can target anti-cancer drugs directly to tumor tissue for loco-regional treatment with enhanced bioavailability, local efficacy and reduced toxicity. In this study, the distribution and pharmacokinetics of hyaluronic acid carrier and a conjugated cisplatin anti-cancer drug were tracked by lanthanum (III) [La(III)] affinity tagging of the nanocarrier. The strong binding affinity of La(III) to HA enabled the simple PDF

Review Article

Recommendations for Inpatient Pediatric CPOE/CDS Systems - A Systematic Review

Benjamin Ehlers* and Stephanie Laer

Benjamin Ehlers: Mr. Ehlers conceptualized the review, carried out the systematic review as well as analyses, drafted and revised the manuscript, and approved the final manuscript as submitted. PDF

Research Article

Guanidine-Annellated Heterocycles: Design, Synthesis and Biological Evaluation of Novel 2-Aminopyridoimidazotriazines, Pyridoimidazopyrimidines, Pyridoimidazotriazoles and Pyridoimidazoles

El-Feky HAS1,2*, Imran M1 , Osman AN2

Starting from 2,3-diaminopyridine, several novel 2-amino [2,3:4,5] imidazo [1,2-a] [1,3,5] triazines (2-6), 2- (1H-imidazo [4,5-b] pyridine-2-yl) imino) -2,3-dihydro-1H-imidazoles (7-11), pyrido [2,3,4,5] imidazo [1,2-a] pyrimidones (13-16), 9H [1,2,4] triazolo [4,3:1,2] imidazo [4,5-b] pyridines (20-21) and 1-(1H-imidazo [4,5-b] pyridine-2-yl) -3-methyl-1H-pyrazol-5-ol PDF

Review Article

Medicinal Properties of Strobilanthes crispus: A Review

Cheng HP1 , Koh RY2*, Chye SM2

In spite of the breakthrough innovation in combinatorial chemistry and molecular modelling, natural products, especially medicinal plants remain one of the important sources from which pharmacologically active compounds are isolated, tested and evaluated in the discovery of new drugs, new leads and chemical entities in pharmaceutical development [1-3]. In fact, many PDF