- 19C Trolley Square, Wilmington, DE 19806
- Email : support@bioaccent.org
Knowledge regarding attention impairment in MS and the value of tools used to detect it are lacking. This study aims to uncover the prevalence and clinical/ demographic profile of attention impairment in MS and tries to identify effective clinical and electrophysiological tests to assess attention in MS patients. ...
For more than a decade, there has been increasing interest in epigenetics as a key factor in the molecular mechanisms of health and disease, including cognitive wellbeing [1,2,3,4,5]. It has been said that that if the genome is the cell's cookbook with genes being the recipes, epigenetic markers are sticky-notes telling the chef which recipes ...
Down syndrome is rarely associated with solid tumors in the central nervous system. I report on a female patient diagnosed with basal ganglia germinoma. ...
The underlying causes of diabetes-induced CNS complications are multifactorial and are relatively little understood although it is now evident that blood-brain barrier (BBB) damage plays a significant role in diabetesdependent CNS disorders. Changes in plasma glucose levels (hyper- or hypoglycemia) have been associated with altered BBB transport ...
Although hereditary spastic paraparesis (HSP) is usually restricted to motor disturbances, chief among them being the progressive lower extremity spasticity, it may also present as complicated, with dementia being the most frequent complication. Out of 50 mutations related to HSP, only 7 of them concern autosomal dominant ...
The role that small RNAs (sRNAs) play in health and disease has attracted considerable interest [1,2,3,4,5]. An area of recent speculation is the question as to whether dietary sRNAs are absorbed from the digestive tract and whether this is a form of inter-species / inter-kingdom epigenetic communication [6,7,8,9,10,11]. This possibility ...
Let us first consider gardens from the aspect of nature therapy. Natural botanical environments may help to support cognitive capabilities, mood, and well-being [2,3,4,5,6,7,8,9]. Botanical gardens and natural surroundings provide a multi-sensorial experience which can translate into feelings of peace, tranquility, gratitude, spirituality, ...
A recent study suggested that a healthy diet – one rich in vegetables, fruit, whole grains, nuts, low-fat dairy, and fish – may help support the maintenance of brain volume in the elderly [1]. This diet, a Mediterranean-type diet, is rich a variety of nutrients that have been shown to support brain health via a multitude ...
The prevalence of dementia is increasing with the increasing longevity of the population. The prevalence of dementia is estimated to be 66 million by 2030 [1]. It affects the cognitive domains including attention, memory, language, social cognition, perceptual motor and executive function that interferes with the quality of living [2]. Clinical approach ...
Enriched environments that contribute to life satisfaction have been recommended as part of a holistic approach for wellness and in the treatment of a variety of neurodegenerative conditions [1,2,3,4]. Appropriate, individualized environmental enrichment may help reduce feelings of anxiety among individuals with ...
Several publications have reported extensive efforts to locate a gross genetic mutation which triggers autism spectrum disorder (ASD). Which triggers autismspectrum disorder (ASD)? No one high-impact mutation discovered so far has been found in more than a few severe autism cases. This suggests that no specific gross nuclear defect is the primary etiology of this disease in the majority of ...
This year, 2018, marks the 35th anniversary of Barbara McClintock being awarded the Nobel Prize in Physiology or Medicine for her discovery of genetic transposition or "jumping genes" [1,2,3,4]. Recent studies hint that "jumping genes" (retrotransposons) may be profoundly important to the field of neuroscience [5]. ...
Wilson's disease [WD] is a potentially treatable autosomal-recessive disorder, which present as various protean clinical manifestations. The initial presentation can be hepatic or neurological or other system dysfunction alone.No two patients of WD may have similar clinical characteristics even among the common sib-ship, which leads to delay in diagnosis. ...
Huntington's Disease (HD) is a progressive neurodegenerative disorder and probably the most widely known example of CAG repeat expansion phenotype. The mutant gene responsible is inherited in an autosomal dominant pattern, thus tending to express itself in every generation of an affected family at any time from the first to the eighth ...
Although vertical gaze palsy and nonfluent aphasia are strongly associated with progressive supranuclear palsy (PSP) and progressive nonfluent aphasia (PNFA) respectively, as they are both part of the frontotemporal lobar degeneration (FTLD) spectrum, they share clinical features ...
Over a decade ago, Wainwright and Calnan [1] argued strongly that work stress had reached epidemic proportions within industrialized societies. Recent evidence suggests that little has changed and contemporary workplaces continue to be studied in the search for answers about what causes and what prevents ...
