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Certain DNA damaging agents including chlorambucil, temozolomide, cyclophosphamide, and cisplatin function as anti-cancer agents by indirectly inhibiting DNA synthesis. At the molecular level, these agents hinder DNA synthesis by altering the composition and structure of nucleic acid. Unfortunately, the effectiveness of these agents ...
B-cell lymphomas arise at certain stages of cellular development and maturation, potentially affecting antigen presentation and T-cell recognition. Burkitt's lymphoma (BL) is a highly malignant B-cell lymphoma that is frequently associated with Epstein-Barr virus infection. Although BL can be effectively treated leading to high survival ...
In the current study, we have experimentally and comparatively investigated and compared malignant human cancer cells and tissues before and after irradiating of synchrotron radiation using Photoacoustic Spectroscopy, Photoemission Spectroscopy and Photothermal Spectroscopy ...
Mitochondrion is a membrane-enclosed organelle which functions as the power house of the eukaryotic cells. The main pathway for energy production of eukaryotic cells, oxidative phosphorylation, takes place in the inner membrane of the mitochondria, especially in the cristae. Following the intake of food molecules, ...
The global advancement of digital communication and its direct impact on medical sciences is a phenomenon that would remain with humanity for a long time. This is the motivation for this study: "Fighting Childhood Cancers in Africa through Digital Communication." This qualitative study on how oncologists, paediatric cancer ...
Mitochondrion is a membrane-enclosed organelle which functions as the power house of the eukaryotic cells. The main pathway for energy production of eukaryotic cells, oxidative phosphorylation, takes place in the inner membrane of the mitochondria, especially ...
Role of metformin as an anti-neoplastic agent in the prevention and management of breast cancer has been advocated in past few decades. Several endocrinal mechanisms are involved in the etiopathogenesis of breast cancer. Insulin promotes growth and in vitro survival of malignant mammary cells. High risk for breast ...
Hematologic malignancies account to 25% of all malignancies in pregnancy. Frequency and localization are comparable to those of nonpregnant woman of the same age. This paper presents the challenging in the management of a pregnant patient with malignancy. The therapy of choice of pregnancy-associated ...
Hypercalcemia is rare in urothelial cell carcinoma. When it does occur, it is typically through a PTHrP-mediated process although this case was not found to have a definitive etiology. ...
Germ cell tumors (GCT) represent an assorted group of benign and malignant neoplasms derived from primordial germ cells. Although most GCTs reside in the retro-peritoneal cavity, tumors can also exist in the midline axis of the body including the mediastinum and head and neck regions. The cervical areas encompass the oral cavity, ...
Radiation treatment has immense importance in treatment for cancer patients both in curative and palliative purposes. Modern radiation treatment facilities like IMRT or VMAT are major development in the delivery of radiation therapy with the potential to improve ...
The ability of lung cancer to evade immunosurveillance is ensured by an "immune deficiency state" leading to a tolerance towards tumoral cell's antigens. Then, a theory that supports the anti-tumoral role of the immune system, made its strong proof, by individualization ...
Many diagnostic challenges arise due to insufficient experience with reactive bone marrow changes which can be sometimes confused with neoplastic disorders. ...
Sleep-wake disturbances are common. Description and classification of sleep disorders helped researchers to define precisely roles and interactions between different nervous structures. ...
Vitamin C (ascorbic acid, ascorbate) has a controversial history in cancer treatment. Emerging evidence indicates that ascorbate in cancer treatment deserves re-examination. As research results concerning ascorbate pharmacokinetics and its mechanisms ...
In this paper, we give an outline of an ongoing study to go beyond Freudian mental archetypal model. First, we discuss the essence of numerous problems that we suffer in our sophisticated and modernized society. Then we discuss possibility to reintroduce spirit into human consciousness. While we are aware that much ...
