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Antibodies have become a major tool therapeutic in cancer treatment because of their high target specificity; treatment efficacy, however, seems to be higher if the antibodies used are able to affect multiple, rather than single, molecular targets. ...
The aim of this study was to assess the feasibility and performance of visual inspection of the cervix with acetic acid (VIA) as a primary tool for cervical cancer screening. ...
Sarcomas are neoplastic malignancies that typically arise in tissues of mesenchymal origin. The identification of novel molecular mechanisms leading to mesenchymal transformation and the establishment of new therapies and biomarker has been hampered by several critical factors. First, mesenchymal malignant ...
MicroRNAs (miRNAs) are small endogenous non-coding RNAs (nc-RNAs) that are involved in many physiological processes. The deregulation of miRNAs can cause a number of diseases, including cancer. The aberrant expression of these master regulators makes them important as therapeutic targets. ...
Elevated levels of various cathepsins in cancer and inflammation necessitate exploring their potential inhibitors. Cathepsin L has been a potential drug target in these diseased conditions. In search for novel chemotherapeutic agents with better ...
Pharyngocutaneous fistula (PCF) is the most feared complication postlaryngectomy with a reported incidence varying from 3% to 65%. Some of the factors such as prior radiotherapy, poor nutritional status, and preoperative tracheostomy significantly increase the risk of developing a PCF. ...
Although Wilms tumor is the most common renal neoplasm in the pediatric population, other rare childhood renal neoplasms should be considered in a pediatric patient presenting with an abdominal mass. CCSK represents one of the most common tumors with "unfavorable histology" listed by the National ...
Renal Cell Carcinoma (RCC) are rare in children, constituting less than 0.3% of all tumors and 1.8 – 6.3% of renal neoplasms in children and adolescents younger than 15 years. Xp11.2 RCC is estimated to represent one-third of pediatric RCC. RCC associated with Xp11.2 translocation has recently been discovered ...
The current study was aimed to analyze the tumor tissue of cholangiocarcinoma from patient to identify the biomarkers at the protein level and mRNA level in cancer tissue. The tumor sample was analyzed by gene expression microarray analysis, DNA sequencing and immunohistochemistry. Gene expression analysis ...
Meckel's diverticulum (M.D.) is the most common congenital anomaly of the gastrointestinal tract and is found in 1.2% to 3% of the population. Although the common presentations are diverticulitis and bleeding, it can occasionally have a confusing presentation. We report a one year old boy presenting ...
Obesity rates within the United States are on the rise. Obesity is a known risk factor for various diseases, including cancer. Numerous studies have linked obesity to the incidence and treatment outcomes of breast cancer. However, the risk of obesity may vary between breast cancer subtypes and different racial ...
Immunohistochemistry (IHC) is the group of techniques that use antibodies as specific reagents to identify and demonstrate several cell and tissue components that are antigens. This linking allows locating and identifying the in situ presence of various ...
Chronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia in the western countries. It comprises approximately 7 percent of non-Hodgkin lymphomas [1]. In Canada, the median age at diagnosis is approximately 72 years [2]. There are approximately 4.6 new cases of CLL per 100.000 men and women ...
DNA double helical structure carries the genetic blueprint of the cell and hence integrity of this biomolecule is crucial for all forms of life. Normal body cells grow, divide and die in a controlled manner for the proper functioning of the body. However, any alteration/mutation in the gene can alter the way in which ...
The natural allergy-oncology perspective described herein explores how forced immunity to allergens from the rubber tree Hevea brasiliensis may inhibit tumor growth and metastasizing. The over expression of mast cells and proteins from the Rho family of GTPases has been shown to manifest in ...
Breast cancer is the leading cause of death in women all over the world. Epidemiological survey for the incidence of breast cancer in Scandinavian countries and night shift workers provide enough evidence for the possible relation between light and hormone regulated cancers such as breast cancer and prostate ...
