BAOJ Cancer Research & Therapy

Bioaccent Online Publishing

Published Articles

Novel CYLD1 truncating mutation in Brooke-Spiegler syndrome: A case report

Brooke–Spiegler syndrome (BSS) is a rare, inherited, dominant disorder characterized by development of multiple adnexal cutaneous neoplasms (cilindromas, trichoepithelioma and spiradenoma), typically occurred in the head and neck region, particularly on the scalp, and increasing in size and number ...

Hormetic effect of an Ethanolic Graviola Leaf Extract onHGF-1 cells survival

Plant-extracted compounds have been used for centuries in traditional pharmacopeia. Some of them have proven to be excellent drug alternatives for cancer treatment as they target metabolic pathways that are key to cancer cells such as apoptosis, energy-producing catabolic pathways, and the response to oxidative stress. Since some anticancer drugs have been shown to produce dose dependent biologically opposite effects, it is crucial to determine the range of doses for which the compounds have maximum therapeutic benefits. ...

Construction and testing for anticancer effect of a TheraCour Biopolymer

Polymeric micelles present the most presentable as it can be tailored according to the needs of specific targeting and make it functional. The TheraCour polymers are designed as linear, uniform, homopolymers Comprising Polyethylene Glycol (PEG) as a monomer unit that is heterochemically functionalized and covalently connected with aliphatic chains as ligands. ...

Risk factors for deep surgical site infections and wound dehiscence after open radical cystectomy

Deep Surgical Site Infections (DSSI, i.e. infection beneath the subcutaneous tissue with purulent drainage of deep wound layers) and/or Wound Dehiscence (WD) in patients undergoing Open Radical Cystectomy (ORC) may require secondary treatments. DSSI and WD are responsible for increased length of hospitalization and treatment costs.The aim of our study was to identify risk factors for major complications such as DSSI/WD after ORC. ...

Coexpression of ABCB1 and ABCG2 as prognostic marker for treatment response in acute myeloid leukemia patients

Acute Myeloid Leukemia (AML) is the most common type of acute leukemia, and despite availability of chemotherapeutic drugs, mortality rates remain highly variable, ranging from 90 to 10% [1]. One of main characters of AML is having distinct ...

Pathophysiology of COVID 19

In late 2019, in late December, a virus now called SARS-CoV-2 caused unusual respiratory illnesses in Wuhan, Hubei Province, China. The disease was called COVID-19. The virus is contagious to humans and has caused a worldwide outbreak. ...

High Sensitivity Detection of Tumor Gene Mutations

It is widely accepted that cancer develops as a results of mutations in cell growth pathway related genes particularly those mutations that occur in growth factor receptor pathways such as the cell surface Epidermal Growth Factor ...

Stat3 as Potential Biomarker in Chronic Myeloid Leukemia Patients

The search for non-invasive tools for cancer diagnosis and management is extremely important. STAT3 shows potential as a biomarker since it is present in the serum of healthy individuals. This study aimed at assessing the relationship ...

Evidence for Biphasic Effects and Differential Expression of Melatonin (MLT) Receptors in Oral Squamous Cell Carcinomas.

Previous work from this group has demonstrated that melatonin (MLT) is capable of significantly altering the growth and viability of oral cancer cell lines. The objective of this study was to explore the receptors that may modulate MLT effects in oral cancers. ...

Alveolar echinococcus: A rare case with atypical localization

Alveolar echinococcus is a chronic parasitic infection, especially hepatobiliary system is involved, portal and biliary tract invasions are frequent, they have indistinct borders can behave just like malignant masses, may invade adjacent organs ...

Dietary curcumin modulates phenobarbital- and acetone-induced CYP450 2B1 and 2E1 isozymes in mice

Curcumin pretreatment has been shown to inhibit benzo(a)pyrene-induced cytochrome P450 1A1/1A2 isozymes in liver and lungs of mice, via its modulatory effect on their transcriptional regulator, aryl hydrocarbon receptor. However, its effects on the activities ...

Trends in Adoptive Tumor Infiltrating Lymphocytes (TILs) Therapy

Adoptive T cell therapy based on tumor infiltrating lymphocytes (TILs) is the most effective treatment for malignant melanoma. The TILs therapy has demonstrated high overall response rates, resulting in tumor regression and prolonged survival in ...

Adrenal Myelolipoma Associated with Focal Segmental Glomerulosclerosis: A Case Report

Adrenal myelolipoma is a rare and usually slow-growing benign tumour. It is composed of hematopoietic and fatty tissue in different proportions, and it is frequently an asymptomatic finding during radiologic tests. ...

Co‐Electroporation with Xenopus Laevis Oocytes Reprograms Normal and Cancerous Human Cells to Resemble Reprogramming Normal and Cancerous Human Cells to Resemble induced Human Pluripotent Stem Cells

To investigate reprogramming human cells into induced pluripotent stem cells (iPSc) using co‐electroporation with Xenopus laevis oocytes. ...

Pharmacy Consultation Outcomes During a Lung Cancer Awareness Campaign

Lung cancer remains a condition that is frequently diagnosed too late for optimum prognosis [1]. Several factors seem to contribute to this, but there is good evidence that response to potential symptoms of lung cancer and awareness of the condition ...

Smoldering (asymptomatic) Multiple Myeloma: Cure-versus-control Debate

Smoldering (asymptomatic) multiple myeloma (SMM) was first described in 1980 by Kyle and Greipp. SMM is a diagnosis largely based on laboratory findings and represents an intermediate clinical stage between monoclonal gammopathies ...