BAOJ Pharmaceutical Sciences

Bioaccent Online Publishing

Published Articles

Cabozantinib Loaded DSPE-PEG2000 Micelles as Delivery System: Formulation, Characterization and Cytotoxicity Evaluation

Cabozantinib, a potent pan-tyrosine kinase inhibitor, has been reported to provide enhanced antitumor efficacy by simultaneously inhibiting both MET and VEGF pathways, which are critical to tumor angio-genesis, survival and migration. Its very poor water solubility prevents its administration by the intra-venous route, which may be important in patients unable to take the drug ...

A Lanthanum-Tagged Chemotherapeutic Agent HA-Pt to Track the In Vivo Distribution of Hyaluronic Acid Complexes

Hyaluronic acid drug conjugates can target anti-cancer drugs directly to tumor tissue for loco-regional treatment with enhanced bioavailability, local efficacy and reduced toxicity. In this study, the distribution and pharmacokinetics of hyaluronic acid carrier and a conjugated cisplatin anti-cancer drug were tracked by lanthanum (III) [La(III)] affinity tagging of the nanocarrier. The strong binding affinity of La(III) to HA enabled the simple ...

Recommendations for Inpatient Pediatric CPOE/CDS Systems - A Systematic Review

Benjamin Ehlers: Mr. Ehlers conceptualized the review, carried out the systematic review as well as analyses, drafted and revised the manuscript, and approved the final manuscript as submitted. ...

Guanidine-Annellated Heterocycles: Design, Synthesis and Biological Evaluation of Novel 2-Aminopyridoimidazotriazines, Pyridoimidazopyrimidines, Pyridoimidazotriazoles and Pyridoimidazoles

Starting from 2,3-diaminopyridine, several novel 2-amino [2,3:4,5] imidazo [1,2-a] [1,3,5] triazines (2-6), 2- (1H-imidazo [4,5-b] pyridine-2-yl) imino) -2,3-dihydro-1H-imidazoles (7-11), pyrido [2,3,4,5] imidazo [1,2-a] pyrimidones (13-16), 9H [1,2,4] triazolo [4,3:1,2] imidazo [4,5-b] pyridines (20-21) and 1-(1H-imidazo [4,5-b] pyridine-2-yl) -3-methyl-1H-pyrazol-5-ol ...

Medicinal Properties of Strobilanthes crispus: A Review

In spite of the breakthrough innovation in combinatorial chemistry and molecular modelling, natural products, especially medicinal plants remain one of the important sources from which pharmacologically active compounds are isolated, tested and evaluated in the discovery of new drugs, new leads and chemical entities in pharmaceutical development [1-3]. In fact, many ...

Characterization of the Major Components in Different Green Tea Dietary Supplements using HPLC and Multivariate Statistical Analysis

Green tea dietary supplements are sold all over the world, and consumers are buying record amounts of green tea products every year. However, the qualities of the products are poorly controlled, which may not only varies the benefit but also hurt the costumer. The purpose of this paper is to compare the contents of the major components in different Green tea supplements. ...

National Pharmacy Administration Programs at Ministry of Health in Saudi Arabia

General Administration of Pharmaceutical Care of Ministry of Health (GAPD-MOH) is founded in December 13, 2001 by decision of Minster of Health number 2286/1/29, and passed through four major phases. Initial Phase from 2000-2001 it is boring period, Construction Phase from 2001-2007 it is building of basic pharmacy administration and pharmacy practice, Development Phase from 2007-2012 stating of new strategic ...

Prognosis with Proton Pump Inhibitor Versus H2 Blocker Therapy in Clostridium Difficile Infection

An 83-year-old female patient recovered from her primary Clostridium difficile-associated colitis upon antibiotic treatment and the suspension of her regular proton pump inhibitor (PPI) therapy, and had a recurrence of the infection once PPI was restarted. After the treatment of the recurrent episode, the PPI was replaced with a histamine H2 receptor blocker, and she ...

Dysfunctional Findings in EEG about 18 Cases were seen in Consultation in our Hospital.

Medical note: "NOT ... any pathology is structural. Dysfunctional cases were entering the EEG. Before starting a premise we specialize in clinical neurophysiology with an experience in the last 14 years of about 12,500 ELECTROENCEFALOGRAMAS- about EEG. And so we can say positively, which is set forth below is very ...

Tyrosine Rich Fraction as an Immunomodulatory Agent from Ficus Religiosa Bark

Ficus religiosa Linn (Moraceae) is being used in traditional medicine to improve immunity hence, petroleum ether and 70% ethanol extracts (50 and 100 mg/kg, i.p.) of F. religiosa bark were screened for immunomodulatory activity by delayed type hypersensitivity (DTH), neutrophil adhesion test and cyclophosphamide-induced neutropenia in Swiss albino mice. 70% ethanol extract ...

An Insight into Antidiabetic Mechanisms of Polyphenol Rich (Catechin, Epicatechin) Tamarind Seeds

Tamarindus indica L. is widely used as a traditional medicine for the management of diabetes mellitus beside its antihepatotoxic and anti-inflammatory activity. However, the influence of Tamarind seed on hyperglycemia and gastrointestinal dysfunctions of diabetes has not been explored so far at molecular level. The effect of 4 weeks oral treatment (120 and 240 mg/kg) of HPLC standardized Tamarind Seed aqueous extract (TSE) was ...

Enteric Coated Iron Folic Acid Tablets: Compromised Efficacy at Cost of Safety

Iron is essential for the synthesis of hemoglobin in erythrocytes and its deficiency can causes Anemia. An estimated 1.62 billion people are suffering from Anemia worldwide with its highest prevalence in developing countries specially India. Therefore, Government of India has started a strategic nutritional and weekly iron folic acid supplementation (WIFS) program to reduce ...

The Antinociceptive Effect of GW5074 in C57BL/6 Mice

Visceral pain is one of the most common type of pain in mammals, however its mechanisms of action has not clearly been understood. In common sense, prostaglandins are released depending on tissue damage to reduce the threshold of pain receptors. Thus, pharmacological inhibition of c-Raf kinase signaling ...

Introduction to Clinical Toxicology Laboratories Testing Control Pharmaceuticals

Drug abuse is a serious challenge in US. According to the report of the Drug Abuse Warning Network, more than 50% of the patients involved the abuse of control pharmaceuticals such as taking more than the prescribed dose of a prescription [1]. A more serious concern is that the control pharmaceuticals was taken by healthy individuals. This challenge is more specific in pain management with opioids such as morphine, oxycodone, oxymorphone, hydrocodone, hydromorphone, dihydrocodeine, methadone, meperidine, fentanyl, and buprenorphine. ...

Pharmaceutical, Surgical, Wound Care "Moving Into the Future"

Dr. Joseph Smith has after many years of research submitting a new development after being picked in April 17-20, 2010 by the SAWC for an Oral Award on my first patent, developed a patented engineered design in addition to (US PAT. # 6776769 BS 2 an application of a cap (US201201363A1), in Advanced Wound Care, Pharma, Biologics that offers better protection for people ...

Pharmaceutical Organizational Change: Redefining Regulatory Science Learning

This paper looks at organizational changes in the pharmaceutical industry's environment using the classic Kotter (1996) 8 Step model and has made an argument that the model can be used successfully in regulatory science learning. The literature on both change management and regulatory science learning was reviewed to see how both topics related to Kotter's 8 Step model. ...