International Journal of Drug Safety and Discovery

Bioaccent Online Publishing

Published Articles

An in silico Approach to Predict Susceptibility to DILI in Metabolic Syndrome: An Alternative to Animal Experiments

Metabolic disorders, such as type 2 diabetes and atherosclerosis form a cluster of different conditions caused and mediated by complex multi-molecular interactions. The presence of metabolic syndrome (MetS) is reported to predispose an individual to drug-induced liver injury (DILI), from drugs such as acetaminophen, halothane, statin. However, the molecular mechanisms ...

Nano-Fourier Transform Infrared Imaging Based on Atomic Force Microscopy for Milk Analysis

Mid-infrared (MIR) spectroscopy is a widely used tool for chemical group identification and molecular structure analysis in chemical, pharmacy, agricultural and food related-samples. However, the diffraction limit prevents the commonly used MIR spectroscopy from mapping on nano-scale particle studies. In this paper, we introduce an imaging of milk ...

Inactivation of Anti-Aging Genes is Related to Defective Drug Metabolism in Diabetes

Healthy diets have been encouraged to reverse non alcoholic fatty liver disease (NAFLD) and accelerate hepatic drug metabolism in diabetes. The amount, nature of fat consumed and time of day of fat consumption has become important [1] with relevance to hepatic drug metabolism [2] and the brain regulation of drug transport that may interfere with brain amyloid beta metabolism relevant to Alzheimer's disease and neurodegenerative disease [3]. The understanding the molecular ...

An Efficient Test Battery for Rapid Screening of Extrapyramidal Side-Effects of Phenothiazine Analogues

Extrapyramidal symptoms (EPS) are undesired side-effects of antipsychotic treatments which include tremors, akathisia and Parkinsonism. The new generation of antipsychotics are expected to induce less EPS, however, these EPS still occurred in patients. The aim of this study was to optimize and implement a novel and robust protocol to evaluate the apparition of EPS and rank the intensity ...

A Novel use of Psychiatric Drug

A case demonstrating the successful use of the benzodiazepine Diazepam to treat chronic vestibular neuronitis with severe vertigo is presented. The implications of the novel use of this psychiatric drug and a discussion on the probable pharmaco-kynetics involved follow. ...

Healthcare Disparities: Skin Color and Accessibility to Healthy Food

The call to remove unfair disparities rings louder this year than any time before. With our current state of affairs, the theme of diversity is intertwined deeply in not only medicine but public health and the dayto- day life of pretty much everyone. It should be noted that healthcare, and more importantly health stems from more than just the services delivered in the clinic, but the accumulation ...

Systemic Contact Dermatitis and Patch Testing in Patients Receiving Orthopedic Implants

Contact dermatitis is defined as a cutaneous inflammatory response to an allergen. While cutaneous reactions to metals such as chromium, cobalt, and nickel are common causes of contact dermatitis, cutaneous reactions to implanted orthopedic devices is a rare finding [1]. Contact dermatitis presents as an erythematous rash on exposed areas of the skin while sparing unaffected areas. ...

Traditional Approach in the Treatment of Malaria in Africa

For WHO (World Health Organization); traditional medicine (TM) can be defined as the knowledge, skills and practices of holistic health care, recognized and accepted for its role in the maintenance of health and the treatment of diseases. It is based on indigenous theories, beliefs and experiences that are handed down from generation ...

An Assessment of the US and UN Safety Precautions for Pesticides in Milk by Labeling Medicine Alarm Strategy for all Dairy Animal Products

Concurrent outbreaks of diseases in ruminants have currently focused attentions on the significance of animal feed and human food contamination with mycotoxins in the induction of malignant diseases and cancer. Many data indicate that even very small quantities of pesticides are carcinogenic; however, to date no data clearly show that significant levels of these formulas are reaching ...

Halothane Anesthesia – Fact or Fallacy?

The goal of a clinical practice guideline is to distil a systematic review of evidence into recommendations intended to optimize patient care. Every year, a large number of Arcton bottles are produced. However, few studies have investigated the mechanism of the reaction of anesthetic general and anesthetic drugs, in humans and animals as mice. For instance, still no study can give an evidence ...

Conventional Culture Media: an Outdated Microbiological Tool but Still Useful

Conventional culture media are the backbone for many microbiological activities in clinical, research, industrial and other fields. They are cheap, easy to handle and convenient. For many decades, they served mankind in the advances made in the microbiological field. However, in the recent years, the limitations of these old tools became ...

Scope and Challenges of Social Pharmacy in Training of Pharmacy Students

Pharmacy practice and curriculum have undergone significant changes over decades. As a consequence of this evolution, pharmacists are more involved in direct interactions with patients and community to ensure the rational use of medicines. To better fulfil this function, future pharmacists need to be well-trained to understand ...

Biomarkers in Health Product Development: Commentary

As defined in a previous case report by Archambault and Plourde (2017), a biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention based on scientific evidence [1]. Archambault and Plourde (2017), using supporting example from patient with advanced prostate cancer has indicated that biomarkers ...

Do Automated Dispensing Device improve Medication Safety and Reducing Medication Error?

Improving Medication safety is always a key focus in the hospital setting, and pharmacists have been exploring a variety of strategies and technologies to achieve this goal. Automated dispensing machines decentralized medication distribution systems that provide computercontrolled storage, dispensing, and tracking of medications have been recommended as one potential mechanism ...

Infections and Immunity of Nipah Virus Outbreaks

Nipah virus is an RNA virus and belongs to the genus Henipavirus. The virus can spread between people and also from other animals but requires a direct contact with the infected source. Nipah virus causes viral infection which is referred as Nipah virus infection (NiV) and the symptoms of NiV vary from none to fever, cough, headache, shortness of breath, confusion, death, etc. ...