BAOJ Cancer Research & Therapy

Bioaccent Online Publishing

Published Articles

Pathophysiology of COVID 19

In late 2019, in late December, a virus now called SARS-CoV-2 caused unusual respiratory illnesses in Wuhan, Hubei Province, China. The disease was called COVID-19. The virus is contagious to humans and has caused a worldwide outbreak. ...

High Sensitivity Detection of Tumor Gene Mutations

It is widely accepted that cancer develops as a results of mutations in cell growth pathway related genes particularly those mutations that occur in growth factor receptor pathways such as the cell surface Epidermal Growth Factor ...

Stat3 as Potential Biomarker in Chronic Myeloid Leukemia Patients

The search for non-invasive tools for cancer diagnosis and management is extremely important. STAT3 shows potential as a biomarker since it is present in the serum of healthy individuals. This study aimed at assessing the relationship ...

Evidence for Biphasic Effects and Differential Expression of Melatonin (MLT) Receptors in Oral Squamous Cell Carcinomas.

Previous work from this group has demonstrated that melatonin (MLT) is capable of significantly altering the growth and viability of oral cancer cell lines. The objective of this study was to explore the receptors that may modulate MLT effects in oral cancers. ...

Alveolar echinococcus: A rare case with atypical localization

Alveolar echinococcus is a chronic parasitic infection, especially hepatobiliary system is involved, portal and biliary tract invasions are frequent, they have indistinct borders can behave just like malignant masses, may invade adjacent organs ...

Dietary curcumin modulates phenobarbital- and acetone-induced CYP450 2B1 and 2E1 isozymes in mice

Curcumin pretreatment has been shown to inhibit benzo(a)pyrene-induced cytochrome P450 1A1/1A2 isozymes in liver and lungs of mice, via its modulatory effect on their transcriptional regulator, aryl hydrocarbon receptor. However, its effects on the activities ...

Trends in Adoptive Tumor Infiltrating Lymphocytes (TILs) Therapy

Adoptive T cell therapy based on tumor infiltrating lymphocytes (TILs) is the most effective treatment for malignant melanoma. The TILs therapy has demonstrated high overall response rates, resulting in tumor regression and prolonged survival in ...

Adrenal Myelolipoma Associated with Focal Segmental Glomerulosclerosis: A Case Report

Adrenal myelolipoma is a rare and usually slow-growing benign tumour. It is composed of hematopoietic and fatty tissue in different proportions, and it is frequently an asymptomatic finding during radiologic tests. ...

Co‐Electroporation with Xenopus Laevis Oocytes Reprograms Normal and Cancerous Human Cells to Resemble Reprogramming Normal and Cancerous Human Cells to Resemble induced Human Pluripotent Stem Cells

To investigate reprogramming human cells into induced pluripotent stem cells (iPSc) using co‐electroporation with Xenopus laevis oocytes. ...

Pharmacy Consultation Outcomes During a Lung Cancer Awareness Campaign

Lung cancer remains a condition that is frequently diagnosed too late for optimum prognosis [1]. Several factors seem to contribute to this, but there is good evidence that response to potential symptoms of lung cancer and awareness of the condition ...

Smoldering (asymptomatic) Multiple Myeloma: Cure-versus-control Debate

Smoldering (asymptomatic) multiple myeloma (SMM) was first described in 1980 by Kyle and Greipp. SMM is a diagnosis largely based on laboratory findings and represents an intermediate clinical stage between monoclonal gammopathies ...

Treatment with Tenascin C Antibody and/or α-Mangostin Reduces Tumor Growth and Lymph Node Metastasis in a Model of Metastatic Mammary Cancer

Antibodies have become a major tool therapeutic in cancer treatment because of their high target specificity; treatment efficacy, however, seems to be higher if the antibodies used are able to affect multiple, rather than single, molecular targets. ...

A Pilot Study to Evaluate the Accuracy of Visual Inspection of the Uterine Cervix with Acetic Acid at a Tertiary Care setting in Kinshasa, DR Congo

The aim of this study was to assess the feasibility and performance of visual inspection of the cervix with acetic acid (VIA) as a primary tool for cervical cancer screening. ...

Biological Characterization of the Uterine Malignant Mesenchymal Tumours

Sarcomas are neoplastic malignancies that typically arise in tissues of mesenchymal origin. The identification of novel molecular mechanisms leading to mesenchymal transformation and the establishment of new therapies and biomarker has been hampered by several critical factors. First, mesenchymal malignant ...

MicroRNA Therapeutics: Basic Principles, Barriers and Perspectives

MicroRNAs (miRNAs) are small endogenous non-coding RNAs (nc-RNAs) that are involved in many physiological processes. The deregulation of miRNAs can cause a number of diseases, including cancer. The aberrant expression of these master regulators makes them important as therapeutic targets. ...

2'-Hydroxychalcones and their Cyclized Derivatives as Cathepsin L Inhibitors

Elevated levels of various cathepsins in cancer and inflammation necessitate exploring their potential inhibitors. Cathepsin L has been a potential drug target in these diseased conditions. In search for novel chemotherapeutic agents with better ...